منابع مشابه
Non-VKA Oral Anticoagulants: Accurate Measurement of Plasma Drug Concentrations
Non-VKA oral anticoagulants (NOACs) have now widely reached the lucrative market of anticoagulation. While the marketing authorization holders claimed that no routine monitoring is required and that these compounds can be given at fixed doses, several evidences arisen from the literature tend to demonstrate the opposite. New data suggests that an assessment of the response at the individual lev...
متن کاملPrediction of pharmacokinetic drug/drug interactions from In vitro data: interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants.
CYP2C9 is involved in the metabolism of the oral anticoagulants warfarin, phenprocoumon, and acenocoumarol. It is also responsible for the 5'-hydroxylation of the nonsteroidal anti-inflammatory drug lornoxicam. Therefore, lornoxicam and the oral anticoagulants are potential inhibitors of their metabolism. Their inhibitory potency was investigated in microsomes from six human livers. An approach...
متن کاملOral Presentations Mechanism of Ethanol-drug Interactions
not submitted DILEMMAS AND CROSSROADS OF PHARMACOTHERAPY OF ALCOHOLISM
متن کاملThe new oral anticoagulants.
Although their first application in clinical practice occurred in the 1940s, vitamin K antagonists remain the only form of oral anticoagulant medication approved for long-term use. Although the available vitamin K antagonists are highly effective for the prevention and/or treatment of most thrombotic disease, the significant interpatient and intrapatient variability in dose-response, the narrow...
متن کاملSpecial feature Oral anticoagulants
Oral anticoagulants are used to manage a variety of common age-related conditions (e.g., atrial fibrillation), and the frequency of their use will likely rise significantly in the United States as the population ages. The number of elderly Americans 65 years of age or older is expected to increase markedly over the next two decades, from 39.6 million in 2009 to 72.1 million by 2030. Nearly one ...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2020
ISSN: 2279-0780,2319-2003
DOI: 10.18203/2319-2003.ijbcp20205541